Endocrine Abstracts

Introduction: Diabetic osteoarthropathy (D.O) commonly referred to as Charcot’s foot is a complication secondary to neuropathic and inflammatory osteolysis, occurring in a setting of old and/or poorly controlled diabetes. Its pathophysiology remains poorly understood and its diagnosis must be systematically evoked in the presence of any inflammatory sign that localised to the foot or ankle occurring on a background of diabetic neuropathy.Clinical ca...

Introduction: Human immunodeficiency virus (HIV) infection and certain antiretroviral (ARV) treatments are associated with an increased risk of developing certain chronic comorbidities including type 2 diabetes, which is more prevalent in HIV-infected individuals. The coexistence of diabetes and HIV infection makes the standard of care more complex. The objective of this work is to discuss the relationship between these two comorbidities and to update physicians on the diagnos...

Introduction: Malignant tumors, nevertheless, have been associated with extremely high circulating ACTH and cortisol levels, and short duration of symptoms of Cushing syndrome (CS) besides atypical clinical phenotype, when compared with pituitary-dependent Cushing. Identification of the source of ACTH can be challenging, as sometimes the primary lesion is not identified even after prolonged and repeated follow-upCase report: A 33-year-old woman with a hi...

Introduction: Familial neurohypophysial diabetes insipidus (FNDI), an autosomal dominant disorder, comes in many forms that are differentiated by the inheritance pattern and the underlying genetic lesion. The disease is caused by mutations in the vasopressin-neurophysin 2-copeptin protein (AVP-NPII), in wolframin (WFS1) or in proprotein convertase subtilisin/kexin type 1 (PCSK1) genes.Materials and methods: In this study, we report a case of familial neu...

Introduction: Hypothalamic-pituitary involvement during sarcoidosis is rare, less than 1%. Granulomatous infiltration can lead to anteropituitary insufficiency, disconnection hyperprolactinemia and diabetes insipidus. We report a case of hypothalamic-pituitary sarcoidosis with review of the literature.Observation: Patient aged 39 years, she complains of chronic headaches for 10 months without decrease in visual acuity, secondary amenorrhea for 6 months. ...

Introduction: Carotid body tumor is a hypervascular tumor with multiple feeding arteries and unique orientation at the carotid bifurcation. Although resection is a radical therapy for this tumor, complete resection is challenging.Case report: A 33-year-old female patient consulted with a neck swelling that had persisted for 3 years. On physical examination, a movable and pulsating hard mass was found on the left side of her neck. Computed tomography, mag...

Introduction: Intermittent Cushing’s syndrome is characterized by alternating episodes of hypercorticism with periods of eucorticism. It is a rare but well-defined entity and should be known. It remains a diagnostic challenge sometimes particularly difficult in endocrinology, we report a case.Case presentation: A 22-year-old diabetic patient on metformin, who consulted us because of a weight gain with the appearance of stretch marks for 2 months. Th...

Introduction: Pituitary apoplexy is a serious medical complication of a pre-existing pituitary adenoma characterized by a variety of clinical symptoms ranging from mild headache to neurologically impaired and finally comatose patients.Case report : We report a case of apoplexy in a large prolactinoma resulting in empty sella syndrome with a successful pregnancy. Our patient is a 31-year-old female, with a history of macroprolactinoma for approximately 7y...

Introduction: Lymphocytic hypophysitis is a rare inflammatory disease of the pituitary gland of autoimmune origin, related to a diffuse infiltration of the pituitary gland sometimes leading to severe hypopituitarism. It is frequent in pregnant or postpartum women.Case report: A 28 year old female patient, followed up for pituitary microadenoma with prolactin for 5 years under dostinex 1 tablet/week who reported headaches with visual acuity decrease with ...

Introduction: Medical treatment of acromegaly with somatostatin analogues (SAs) has been used for a long time and is a well-established treatment in cases where surgery, which is the first-line treatment, is impossible or inadequate. We report a case of acromegaly under control after initiation of Lanreotide.Observation: Patient aged 59 years, referred for acromegaloid dysmorphic syndrome initially with tumor syndrome with IGF1 workup at 729 ng/mL (norma...